Custom build with these?
You'd need to drop the belt drive, but gain the option of converting to geared at some point.
Also, the rear disc caliper is on the outside, which is one thing i would like on my pompetamine. The inside position is just annoying to properly align the caliper when the wheel is towards the back of the dropouts.
Have you seen the monstercross thread on mtbr.com? Loads of similar setups there.
Monstercross thread
Tyres and clearances? My pompetamine takes 35 plus fenders, or 42 without. More clearance than that would be pretty cool, but not sure how it works out with frame geometry? Your bike is going to be massive anyway :P